• V Torres-Degayón, J M Torres-Murillo, M I Baena-Parejo, M C Muñoz-Villanueva, G Montes-Redondo, M A Calleja-Hernández, and M J Faus-Dáder.
• Pharmacy Department, Ceuta University Hospital, Ceuta, Spain.
• J Clin Pharm Ther. 2015 Aug 1; 40 (4): 452-60.

What Is Known And ObjectiveMedication is the main treatment option for patients with chronic atrial fibrillation. However, medication can have negative effects. We aimed to detect negative outcomes associated with medication that led to patients with chronic atrial fibrillation presenting themselves to hospital emergency departments. We assessed the severity of those outcomes and comment on whether they could have been avoided.MethodsThis descriptive, cross-sectional study included all patients with chronic atrial fibrillation who attended the emergency department of our tertiary hospital. We used the Dader method to identify and evaluate the negative outcomes associated with medication through interviews with patients and scrutiny of the clinical charts.Results And DiscussionOf the 198 eligible patients who presented at the emergency department, 134 (67·7%) did so because of negative outcomes associated with medication (41% related to necessity, 32·1% to effectiveness and 26·9% to safety); 67·9% of those negative outcomes could have been avoided. In terms of severity, 6·7% were mild, 31·3% moderate, 51·5% severe and 10·4% fatal. The Anatomical Therapeutic Chemical Classification anatomical group most frequently associated with negative outcomes was the cardiovascular system, followed by blood/blood-forming organs.What Is New And ConclusionA high percentage of patients with chronic atrial fibrillation presenting at hospital emergency departments had negative outcomes associated with medication. Some led to deaths. More than half of these were severe, and most could have been avoided.© 2015 John Wiley & Sons Ltd.

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