• Baillieres Clin. Haematol. · Dec 1993

    Review

    Chronic lymphoproliferative disorders: classification and diagnosis.

    • C E Litz and R D Brunning.
    • Laboratory Medicine and Pathology, University of Minnesota Medical School, University of Minnesota Hospital, MN 55455.
    • Baillieres Clin. Haematol. 1993 Dec 1; 6 (4): 767-83.

    AbstractThe chronic lymphoproliferative disorders are morphologically, immunologically and clinically heterogeneous. Common features of these processes include T, B or natural killer cell immunophenotypes and terminal deoxy-nucleotidyl transferase negativity. The B cell lymphocytic disorders include B-chronic lymphocytic leukaemia, B cell prolymphocytic leukaemia, chronic lymphocytic leukaemia-prolymphocytic leukaemia, non-Hodgkin's lymphoma (including mantle cell lymphoma) in leukaemic phase, hairy cell leukaemia and splenic lymphoma with villous lymphocytes. The T cell chronic lymphoproliferative disorders include prolymphocytic leukaemia, adult T cell leukaemia-lymphoma, large granulated lymphocyte leukaemia and Sézary syndrome. Occasionally, a lymphocytic proliferation is encountered that does not satisfy the morphological or immunophenotypical criteria for any of the above categories. These processes are best left unclassified.

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