• Weifei Wu, Yuanli Du, Jie Liang, Ying Chen, Xiaoyi Tan, Xuanping Xiang, Wanhong Wang, and Neng Ru.
• Departments of *Orthopedics and †Nephrology, the People's Hospital of Three Gorges University, the First People's Hospital of Yichang, Yichang, Hubei Province, China.
• Spine. 2014 Feb 1;39(3):256-62.

Study DesignA comparative study.ObjectiveThe aims of this study were to: (1) evaluate Scoliosis Research Society (SRS)-22 questionnaire performance in normal adolescents without scoliosis to establish a normative baseline useful for evaluating the discriminate validity of the SRS-22 in primary adolescent scoliosis; and (2) investigate impact of age and sex on SRS-22 in an adolescent population unaffected by scoliosis.Summary Of Background DataThe SRS-22 questionnaire is widely used to measure health-related quality of life of patients with spinal disease including scoliosis and lumbar spondylolisthesis. However, normal data, which are very important, when comparing patients and nonpatients, are few, little, and there are few studies about factors that may affect SRS questionnaire performance.MethodsThe adolescent population was from 14 schools located in 7 provinces. A total of 2008 adolescents (961 females, 1026 males, 21 unknown; mean age, 14.3 yr; range, 11-20) completed the simplified Chinese version of SRS-22 questionnaire and demographic questions. Surveys were stratified into 8 age-sex groups for analysis: male/female; 12 to 13.4, 13.5 to 14.9, 15 to 15.9, and more than 16 years of age. Post hoc testing and the Tukey least significant difference were used to compare differences between any 2 of the 4 age groups.ResultsSelf-image scores in males were higher than those in females (P < 0.01). Pain domain scores were significantly higher in males than those in females in the 13.5- to 14.9-year-old subgroup, whereas other subgroups showed no obvious differences. The function domain scores in males who were aged 15 to 15.9 years and those older than 16 years were significantly higher than those in females (P < 0.001). There were no statistically significant differences in mental health domain scores among age-sex subgroups, with the exception of the 13.5- to 14.9-year-old group.ConclusionThis is the first study to characterize the sex and age influence on the SRS-22 scores in normal population. Age and sex have an important effect on SRS-22 scores, so when using the instrument to assess health-related quality of life of patients with scoliosis or other spinal disease, we should consider the differences in patients with different age and sex.Level Of Evidence3.

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