• Exp. Lung Res. · Mar 2018

    Emphysema induced by elastase alters the mRNA relative levels from DNA repair genes in acute lung injury in response to sepsis induced by lipopolysaccharide administration in Wistar rats.

    • Luiz Philippe S Sergio, Leda M F Lucinda, Maycon M Reboredo, Flavia de Paoli, Lídia M C Fonseca, Bruno V Pinheiro, Andre L Mencalha, and Adenilson S Fonseca.
    • a Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes , Universidade do Estado do Rio de Janeiro , Vila Isabel , Rio de Janeiro , Brazil.
    • Exp. Lung Res. 2018 Mar 1; 44 (2): 79-88.

    AbstractPurpose/Aim of the study: Patients suffering from chronic obstructive pulmonary disease (COPD) in association with acute respiratory distress syndrome (ARDS) present oxidative stress in lung cells, with production of free radicals and DNA lesions in pulmonary and adjacent cells. Once the DNA molecule is damaged, a set of enzymatic mechanisms are trigged to preserve genetic code integrity and cellular homeostasis. These enzymatic mechanisms include the base and the nucleotide excision repair pathways, as well as telomere regulation. Thus, the aim of this work was to evaluate the mRNA levels from APEX1, ERCC2, TP53, and TRF2 genes in lung tissue from Wistar rats affected by acute lung injury in response to sepsis and emphysema.

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