• Francisco López-Medrano, Elisa Cordero, Joan Gavaldá, Josep M Cruzado, M Ángeles Marcos, Pilar Pérez-Romero, Nuria Sabé, Miguel Ángel Gómez-Bravo, Juan Francisco Delgado, Evelyn Cabral, Jordi Carratalá, and Study Group of Infection in Transplant Recipients (GESITRA) of the Spanish Society of Infectious Diseases, Clinical Microbiology (SEIMC), Spanish Network for Research in Infectious Diseases (REIPI).
• Unidad de Enfermedades Infecciosas, Hospital Universitario 12 de Octubre, Instituto de Investigación Biomédica 12 de Octubre (i+12), Departamento de Medicina, Universidad Complutense, Madrid, Spain. Electronic address: flmedrano@yahoo.es.
• Enferm. Infecc. Microbiol. Clin. 2013 Oct 1; 31 (8): 526.e1-526.e20.

BackgroundSolid organ transplant (SOT) recipients are at greater risk than the general population for complications and mortality from influenza infection.MethodsResearchers and clinicians with experience in SOT infections have developed this consensus document in collaboration with several Spanish scientific societies and study networks related to transplant management. We conducted a systematic review to assess the management and prevention of influenza infection in SOT recipients. Evidence levels based on the available literature are given for each recommendation. This article was written in accordance with international recommendations on consensus statements and the recommendations of the Appraisal of Guidelines for Research and Evaluation II (AGREE II).ResultsRecommendations are provided on the procurement of organs from donors with suspected or confirmed influenza infection. We highlight the importance of the possibility of influenza infection in any SOT recipient presenting upper or lower respiratory symptoms, including pneumonia. The importance of early antiviral treatment of SOT recipients with suspected or confirmed influenza infection and the necessity of annual influenza vaccination are emphasized. The microbiological techniques for diagnosis of influenza infection are reviewed. Guidelines for the use of antiviral prophylaxis in inpatients and outpatients are provided. Recommendations for household contacts of SOT recipients with influenza infection and health care workers in close contact with transplant patients are also included. Finally antiviral dose adjustment guidelines are presented for cases of impaired renal function and for pediatric populations.ConclusionsThe latest scientific information available regarding influenza infection in the context of SOT is incorporated into this document.Copyright © 2013 Elsevier España, S.L. All rights reserved.

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