• Pain physician · Mar 2021

    Randomized Controlled Trial

    Efficacy of Genicular Nerve Radiofrequency Ablation Versus Intra-Articular Platelet Rich Plasma in Chronic Knee Osteoarthritis: A Single-Blind Randomized Clinical Trial.

    • Abdelraheem Elawamy, Emad Zarief Kamel, Safaa A Mahran, Hebatallah Abdellatif, and Manal Hassanien.
    • Department of Anesthesia and Intensive Care, Faculty of Medicine, Assuit University, Assiut, Egypt.
    • Pain Physician. 2021 Mar 1; 24 (2): 127-134.

    BackgroundChronic knee osteoarthritis is a common problem with increasing of the aging population. Pulsed radiofrequency and intraarticular platelet rich plasma injection are well evidenced beneficial modalities for pain alleviation in such groups of patients.ObjectiveThe primary goal in this study was to compare the 2 modalities regarding pain alleviation evaluated by visual analog scale. The secondary goal focused upon the change of the Index of Severity for Osteoarthritis of the Knee by Lequesne.Study DesignSingle-blind randomized interventional clinical trial.SettingUniversity hospitals.MethodsTwo hundred patients with chronic knee osteoarthritis were equally and randomly distributed into 2 groups. Group PRF received pulsed radiofrequency, whereas the group PRP received intraarticular platelet-rich plasma. The visual analog scale and index of severity of osteoarthritis were evaluated before intervention, after one week (for visual analog scale only), then after 3, 6, and 12 months.ResultsVisual analog scale was significantly lower in the PRF group compared to the PRP group at 6 and 12 months with P-values of 0.01 and 0.04, respectively. Regarding to the postinterventional index of severity of osteoarthritis, it was significantly lower in the PRF group than the PRP group with P-values of 0.001 at 3, 6, and 12 months follow-up.LimitationsPhysical and analgesic therapy were not included in data collection, and there was no control group.ConclusionPulsed radiofrequency of the genicular nerves can be considered superior to knee intraarticular platelet-rich plasma injection for sustained pain relief and the lower severity index in patients with chronic knee osteoarthritis.

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