• Critical care clinics · Apr 2021

    Review

    Hepatorenal Syndrome.

    • Saro Khemichian, Claire Francoz, Francois Durand, Constantine J Karvellas, and Mitra K Nadim.
    • Division of Gastroenterology/Liver, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA.
    • Crit Care Clin. 2021 Apr 1; 37 (2): 321-334.

    AbstractDevelopment of acute kidney injury in patients with chronic liver disease is common and portends a poor prognosis. Diagnosis remains challenging, as traditional markers, such as serum creatinine, are not reliable. Recent development of novel biomarkers may assist with this. Pathophysiology of this condition is multifactorial, relating to physiologic changes associated with portal hypertension, kidney factors, and systemic inflammatory response. Mainstay of treatment remains use of vasoconstrictors along with albumin. Recent guidelines streamline the selection of patients that will require simultaneous liver and kidney transplantation. Posttransplant kidney injury is common relating to multiple factors.Copyright © 2020 Elsevier Inc. All rights reserved.

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