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Critical care clinics · Apr 2021
ReviewThe Role of Renal Functional Reserve in Predicting Acute Kidney Injury.
- Dana Y Fuhrman.
- Pediatrics, Critical Care Medicine, and Nephrology, Department of Critical Care Medicine, The Center for Critical Care Nephrology, University of Pittsburgh School of Medicine, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Children's Hospital Drive, Faculty Pavilion, Suite 2000, Pittsburgh, PA 15224, USA. Electronic address: dana.fuhrman@chp.edu.
- Crit Care Clin. 2021 Apr 1; 37 (2): 399-407.
AbstractRenal functional reserve (RFR) is described as the difference between a glomerular filtration rate (GFR) measured at baseline and after protein stimulation. The percent change in GFR after a protein load varies based on differences in experimental conditions, with the use of an oral meat protein stimulus and a creatinine clearance method to quantify GFR showing the greatest RFR. A decline in RFR has been found in numerous patient groups. Recent investigations have suggested that a lower RFR may be associated with an increased risk of acute kidney injury and eventual chronic kidney disease.Copyright © 2020 Elsevier Inc. All rights reserved.
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