• Bo Ding, Shilong Fu, Meilin Wang, Cong Yue, Wei Wang, Delan Zhou, Zhengdong Zhang, and Suping Han.
• Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
• Int. J. Gynecol. Cancer. 2012 Feb 1; 22 (2): 213-9.

ObjectiveTumor necrosis factor α (TNF-α), secreted mainly by activated macrophages, is recently involved in fighting against tumorigenesis. Tumor necrosis factor α -308 G>A, the common polymorphism in the promoter of TNF-α, has been implicated to alter the risk of cervical cancer, yet the results of relative studies are inconclusive or controversial. To derive a more precise estimation of the relationship, we performed a meta-analysis based on 8 studies.MethodsA comprehensive search was conducted to examine all the eligible studies of TNF-α -308 G>A polymorphism and cervical cancer risk. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.ResultsEight studies regarding TNF-α -308 G>A polymorphism status including 2298 cases and 1903 controls were collected. Overall, significantly elevated cervical cancer risk was found for A allele versus G allele (OR, 1.25; 95% CI, 1.10-1.42), for GA versus GG (OR, 1.33; 95% CI, 1.14-1.54), and for GA/AA versus GG (OR, 1.31; 95% CI, 1.14-1.52). In the subgroup analysis by ethnicity, significantly increased risks were also found among whites (for A allele vs G allele: OR, 1.16; 95% CI, 1.00-1.34; for GA vs GG: OR, 1.24; 95% CI, 1.05-1.48; and for GA/AA vs GG: OR, 1.22; 95% CI, 1.03-1.44) and Asians (for A allele vs G allele: OR, 2.36; 95% CI, 1.60-3.50; AA vs GG: OR, 3.85; 95% CI, 1.30-11.37; for GA vs GG: OR, 2.06; 95% CI, 1.30-3.27; GA/AA vs GG: OR, 2.29; 95% CI, 1.49-3.52; and for AA vsGa/GgOR, 3.70; 95% CI, 1.25-10.81). However, no significant associations were found among Africans for all genetic models.ConclusionsThe natural genetic polymorphism in TNF-α -308 G>A is a risk factor for developing cervical cancer, especially for Asians and whites.

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