• Eileen E Reynolds, Carol Bates, Martha Richardson, and Risa B Burns.
• Beth Israel Deaconess Medical Center, Boston, Massachusetts (E.E.R., C.B., M.R., R.B.B.).
• Ann. Intern. Med. 2018 Feb 6; 168 (3): 203-209.

AbstractHormone therapy (HT) was widely prescribed in the 1980s and 1990s and has been controversial since the initial results of the Women's Health Initiative (WHI) trial in the early 2000s suggested that it increased risk for breast cancer and coronary heart disease and did not prolong life. However, more recent data and reexamination of the WHI results suggest that HT is safe and effective for many women when used around the time of menopause. Two experts debate the 2017 Hormone Therapy Position Statement of The North American Menopause Society, which recommends HT as first-line treatment of vasomotor symptoms, and apply it to the care of Ms. R, a 52-year-old woman with severe hot flashes, sleep disturbance, and irritability.

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