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Review Case Reports
Metachronous Esophageal Ulcers after Immune-mediated Colitis Due to Immune Checkpoint Inhibitor Therapy: A Case Report and Literature Review.
- Soichiro Ogawa, Hiroshi Kawakami, Sho Suzuki, Daisuke Kuroki, Naomi Uchiyama, Hiroshi Hatada, Toshihiro Gi, and Yuichiro Sato.
- Department of Gastroenterology and Hepatology, Center for Digestive Disease and Division of Endoscopy, University of Miyazaki Hospital, Japan.
- Intern. Med. 2021 Sep 1; 60 (17): 2783-2791.
AbstractAlthough cases of gastrointestinal toxicity of pembrolizumab have been reported, cases of acute immune-mediated colitis accompanied with metachronous esophageal disorders (esophagitis and ulcer) are rare. We herein report a case of acute colitis and metachronous esophageal ulcers due to an immune-related adverse event following concomitant pembrolizumab chemotherapy for lung adenocarcinoma. To our knowledge, there have so far been no reports of cases in which both acute immune-mediated colitis and metachronous esophageal ulcers developed. We therefore report the details of this case along with a review of the pertinent literature.
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