• Iuliana-Marinela Lupu, Zineb Rebaine, Laurence Lhotel, Christine Watremez, Stéphane Eeckhoudt, Michel Van Dyck, and Mona Momeni.
• Department of Anesthesiology, Université Catholique de Louvain, Cliniques universitaires Saint Luc, Brussels, Belgium.
• Ann Card Anaesth. 2018 Jul 1; 21 (3): 262-269.

BackgroundStudies evaluating the hemostatic effects of fibrinogen administration in cardiac surgery are not conclusive.AimsWe investigated whether the use of a low-dose human fibrinogen in case of clinical bleeding after protamine administration and concomitant low FIBTEM values is effective in reducing postoperative bleeding. Secondary end-point was to investigate the consumption of allogeneic blood products.Setting And DesignThis was a retrospective matched study conducted at university hospital.Materials And MethodsAmong 2257 patients undergoing surgery with cardiopulmonary (CPB) bypass, 73 patients received a median dose of 1 g human fibrinogen (ROTEM-Fibri group). This group was matched with 73 patients who had not received human fibrinogen (control group) among 390 patients having undergone surgery at the moment FIBTEM analysis was unavailable.Statistical AnalysisMatching was performed for the type and the presence of redo surgery. McNemar and Wilcoxon paired tests were used to respectively compare the categorical and quantitative variables.ResultsThe CPB bypass time was significantly higher in the ROTEM-Fibri group (P = 0.006). This group showed significantly higher bleeding in the first 12 and 24 h postoperatively (P < 0.001) and required significantly more transfusion of blood products (P < 0.001) and surgical revision (P = 0.007) when compared with the control group. There was no significant difference in the number of thromboembolic complications.ConclusionsThese results show that the administration of 1 g of fibrinogen based on low-FIBTEM values and clinical bleeding after protamine administration does not stop bleeding and the need for transfusion of allogeneic blood products.

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