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Paediatr Respir Rev · Jun 2014
Case ReportsPanton-Valentine Leukocidin-positive Staphylococcus aureus: a potentially significant pathogen in cystic fibrosis.
- Peter J Barry, Barbara J Isalska, and Andrew M Jones.
- Manchester Adult Cystic Fibrosis Centre, University Hospital of South Manchester, Wythenshawe, Manchester, M23 9LT, UK. Electronic address: Peter.Barry@UHSM.NHS.UK.
- Paediatr Respir Rev. 2014 Jun 1; 15 Suppl 1: 22-5.
AbstractStaphylococcus aureus is an important pathogen within the context of cystic fibrosis lung disease. Case reports have identified a strong association between the toxin Panton-Valentine Leukocidin (PVL) and lethal necrotizing pneumonia in healthy immunocompetent patients. PVL+ strains of Staphylococcus aureus have also been identified in patients with cystic fibrosis. We describe a further case of pneumonia in a patient with cystic fibrosis, and outline potential transmission of the organism from healthy family members to this patient. We review the evidence regarding the pathogenicity of PVL toxin with a special reference to patients with cystic fibrosis. We outline current concerns regarding the potential transmission of the organism and possible treatment strategies. Copyright © 2014 Elsevier Ltd. All rights reserved.
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