• Ir J Med Sci · Apr 2022

    Clinical implication of aquaporin 9 in non-small cell lung cancer patients: its expression and relationship with clinical features and prognosis.

    • Peifeng Chen, Qiaolian Li, Yi Zhou, Hong Lu, Hejian Chen, Minjia Qian, and Jinyin Chen.
    • Department of Respiratory and Critical Care Medicine, Zhuji Affiliated Hospital of Shaoxing University, NO. 9 Jianmin Road, Taozhu Streets, Zhuji, Zhejiang, China.
    • Ir J Med Sci. 2022 Apr 1; 191 (2): 651-658.

    BackgroundAquaporin 9 (AQP9) is recognized as a key regulator in several cancers, whereas little is known about its clinical implication in non-small cell lung cancer (NSCLC). Thus, we aimed to explore AQP9 expression and its relationship with clinical features, prognosis in NSCLC patients.MethodsOne hundred ninety-eight NSCLC patients who received resection were retrospectively enrolled. This study contained two cohorts: in cohort A, AQP9 protein expression (from formalin fixed paraffin embedded tumor and paired adjacent tissue specimens) in 198 patients was detected by immunohistochemistry (IHC). In cohort B, AQP9 mRNA expression (from fresh-frozen tumor and paired adjacent tissues) in 108 patients (out of 198 patients) was detected by RT-qPCR.ResultsIn cohort A, increased AQP9 IHC score and greater proportion of AQP9 protein high expression cases were shown in tumor tissue than adjacent tissue (both P < 0.001). Tumor AQP9 protein high expression correlated with lymph node (LYN) metastasis (P = 0.002) and raised TNM stage (P = 0.012). Interestingly, tumor AQP9 protein high expression related to worse disease-free survival (DFS) (P = 0.002) and overall survival (OS) (P = 0.026). In cohort B, AQP9 mRNA expression in tumor tissue was increased than adjacent tissue (P < 0.001), and tumor AQP9 mRNA high expression linked to LYN metastasis (P = 0.024) and increased TNM stage (P = 0.032) as well; tumor AQP9 mRNA high expression was related to shorter DFS (P = 0.009), and it presented with a trend to be correlated with worse OS (P = 0.054), but without statistical significance.ConclusionAQP9 serves as a potential indicator for monitoring disease progression and prognostication in NSCLC patients.© 2021. Royal Academy of Medicine in Ireland.

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