• Akio Saiura, Junji Yamamoto, Rintaro Koga, Yoshihiro Sakamoto, Norihiro Kokudo, Makoto Seki, Takuhiro Yamaguchi, Toshiharu Yamaguchi, Tetsuichiro Muto, and Masatoshi Makuuchi.
• Department of Gastrointestinal Surgery, Cancer Institute, Ariake Hospital, 3-10-6 Ariake, Koto-ku, Tokyo 135-8500, Japan. saiura-tky@umin.ac.jp
• Am. J. Surg. 2006 Jul 1; 192 (1): 41-5.

BackgroundThe goal of the present study was to evaluate the efficacy of the novel LigaSure Vessel Sealing System (Valleylab, Boulder, CO) when used for liver resection.MethodsSixty patients (n = 30 in each group) with liver pathology from a single center were randomized to undergo liver resection with either the LigaSure system or with conventional clamping methods. Patients were stratified according to tumor size (<5 or >5 cm), type of hepatectomy (minor or major), and liver damage (normal or injured). Estimated blood loss during liver transection was used as the primary end point, whereas liver transection speed and morbidity rate were used as secondary end points.ResultsThere were no hospital deaths. The median blood loss during liver transection was less in the LigaSure than in the conventional group (200 vs 322 mL; P = .185). The amount of blood loss during minor hepatectomy was significantly less in the LigaSure than in the conventional group (186 vs 412 mL, P = .012). The liver transection speed was significantly faster in the LigaSure than in the conventional group (2.3 vs 1.6 cm(2)/min, P < .001. The number of ties required during liver transection was significantly less in the LigaSure than in the conventional group (6 vs 69 ties, P < .001). The morbidity rate was similar when comparing the 2 groups, indicating that the LigaSure sealing device and conventional methods had comparable efficacy in sealing the bile duct in the portal triad. Postoperative bile leak was observed in 1 patient (3%) in the LigaSure group and in 3 patients (9%) in the conventional group (P = .301).ConclusionsThe LigaSure system is an effective and safe tool for decreasing liver resection time.

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