• Pham Dang Hai, Nguyen Thanh Binh, Nguyen Viet Quang Hien, Nguyen Huy Hoang, Vu Ngoc Hoan, SonPham NguyenPNhttps://orcid.org/0000-0002-0443-9083Department of Cardiology, 108 Military Central Hospital, Vietnam., and Le Thi Viet Hoa.
• Intensive Care Unit, 108 Military Central Hospital, Vietnam.
• Biomed Res Int. 2020 Jan 1; 2020: 7927353.

BackgroundLeft ventricular (LV) systolic dysfunction is common in septic shock. Global longitudinal strain (GLS) measured by speckle tracking echocardiography (STE) is a useful marker of intrinsic left ventricular systolic function. However, the association between left ventricular GLS and outcome in septic patients is not well understood. We performed this prospective study to investigate the prognostic value of LV systolic function utilizing speckle tracking echocardiography in patients with septic shock.MethodsAll the patients with septic shock based on sepsis-3 definition admitted to the intensive care unit were prospectively studied with STE within 24 hours after the onset of septic shock. Baseline clinical and echocardiographic variables were collected. The primary outcome was in-hospital mortality.ResultsDuring a 19-month period, 90 consecutive patients were enrolled in the study. The in-hospital mortality rate was 43.3%. Compared with survivors, nonsurvivors exhibited significantly less negative GLS (-13.1 ± 3.3% versus -15.8 ± 2.9%; p < 0.001), which reflected worse LV systolic function. The area under the ROC curves of GLS for the prediction of mortality was 0.76 (95% CI 0.67 to 0.87). Patients with GLS > -14.1% showed a significantly higher mortality rate (67.7% versus 15.6%; p < 0.0001; log-rank = 23.3; p < 0.0001). In the multivariate analysis, GLS (HR, 1.27; 95% CI 1.07 to 1.50, p = 0.005) and SOFA scores (HR, 1.27; 95% CI 1.08 to 1.50, p = 0.004) were independent predictors of in-hospital mortality.ConclusionsOur study indicated that LV systolic function measured by STE might be associated with mortality in patients with septic shock.Copyright © 2020 Pham Dang Hai et al.

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