• Lancet · Feb 1989

    348 cases of suspected neonatal alloimmune thrombocytopenia.

    • C Mueller-Eckhardt, V Kiefel, A Grubert, H Kroll, M Weisheit, S Schmidt, G Mueller-Eckhardt, and S Santoso.
    • Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Federal Republic of Germany.
    • Lancet. 1989 Feb 18; 1 (8634): 363-6.

    AbstractSerological and clinical data were collected in 348 cases of suspected neonatal alloimmune thrombocytopenia (NAT). Of the 144 mothers who were Zwa-negative, 107 had Zwa antibodies--alone (94); with HLA antibodies (12); or with Bra antibodies (1). Antibodies were detected in 12 of the 204 Zwa-positive mothers as follows: anti-Bra (9), anti-Zwb (1), anti-Baka with HLA antibody (1), and blood group B isoagglutinins (1). The frequency of NAT due to Bra incompatibility (19%) was second to Zwa (78%). Zwa-NAT was clinically the more severe (14% had intracranial haemorrhages) and responded well to either maternal platelet transfusions or intravenous IgG. In Bra-NAT intracranial haemorrhages were not observed and most children recovered without specific therapy.

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