• Rev Invest Clin · Mar 2021

    Observational Study

    The Sum of Kidney Donor Profile Index and Estimated Post-Transplant Survival Scale and Their Correlation with eGFR Decline in Deceased Donor Kidney Recipients.

    • Pablo Maggiani-Aguilera, Sergio Hernández-Estrada, José H Cano-Cervantes, Jonathan S Chávez-Iñiguez, Christian Pérez-Flores, Odette Del C Díaz-Avedaño, María C Oseguera-Vizcaíno, Mayra Matías-Carmona, Daniel F Ovando-Morga, María G Ramírez-Ramírez, Guillermo Navarro-Blackaller, Marco A Covarrubias-Velasco, José A Torres-Mayorga, Benjamín Gómez-Navarro, and Guillermo García-García.
    • Department of Nephrology, Renal Transplant Unit, Centro Médico Nacional 20 de Noviembre, Institute for Social Security and Services for State Workers (ISSSTE), Mexico City; Posgraduate Faculty, School of Medicine, Universidad Nacional Autónoma de México (UNAM), Mexico City; Mexico.
    • Rev Invest Clin. 2021 Mar 23; 73 (4): 216-221.

    BackgroundThe impact of donor quality on post-kidney transplant survival may vary by candidate condition.ObjectiveAnalyzing the combined use of the Kidney Donor Profile Index (KDPI) and the estimated post-transplant survival (EPTS) scale and their correlation with the estimated glomerular filtration rate (eGFR) decline in deceased-donor kidney recipients (DDKR).MethodsThis was a retrospective, observational cohort study. We included DDKRs between 2015 and 2017 at a national third-level hospital.ResultsWe analyzed 68 DDKR. The mean age at transplant was 41 ± 14 years, 47 (69%) had sensitization events, 18 (26%) had delayed graft function, and 16 (23%) acute rejection. The graft survival at 12 and 36 months was 98.1% (95% CI 94-100) and 83.7% (95% CI 65-100), respectively. The Pearson correlation coefficient between the percentage reduction in the annual eGFR and the sum of EPTS and KDPI scales was r = 0.61, p < 0.001. The correlation coefficient between the percentage reduction in the annual eGFR and the EPTS and KDPI scales separately was r = 0.55, p < 0.001, and r = 0.53, p < 0.001, respectively.ConclusionsThe sum of EPTS and KDPI scales can provide a better donor-recipient relationship and has a moderately positive correlation with the decrease in eGFR in DDKR.

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