• Medicine · Mar 2021

    Meta Analysis

    Comorbidities' potential impacts on severe and non-severe patients with COVID-19: A systematic review and meta-analysis.

    • Sixiang Cheng, Yuxin Zhao, Fenxiao Wang, Yan Chen, Atipatsa Chiwanda Kaminga, and Huilan Xu.
    • Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, Hunan Province.
    • Medicine (Baltimore). 2021 Mar 26; 100 (12): e24971e24971.

    BackgroundAn ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus (SARS-CoV-2) emerged in December 2019 in Wuhan, China. Epidemiologic evidence suggests that patients with comorbidities and novel coronavirus disease 2019 (COVID-19) infection may have poor survival outcomes. However, the risk of these coexisting medical conditions in severe and non-severe cases has not been systematically reported.PurposeThe present study aimed to estimate the association of chronic comorbidities in severe and non-severe cases.MethodsA literature search was conducted using the databases PubMed, Embase, China National Knowledge Infrastructure (CNKI), and Wanfang Database, Chinese Scientific Journals Full-text Database (CQVIP) from the inception dates to April 1, 2020, to identify cohort studies assessing comorbidity and risk of adverse outcome. Either a fixed- or random-effects model was used to calculate the overall combined risk estimates.ResultsA total of 22 studies involving 3286 patients with laboratory-confirmed COVID-19 were included in the analysis. Overall, compared with the patients with non-severe cases, the pooled odds ratios (ORs) of hypertension, diabetes mellitus, and cardiovascular, cerebrovascular, and respiratory diseases in patients with severe cases were 2.79 (95% confidence intervals [95% CI]: 1.66-4.69), 1.64 (95% CI: 2.30-1.08), 1.79 (95% CI: 1.08-2.96), 3.92 (95% CI: 2.45-6.28), and 1.98 (95% CI: 1.26-3.12), respectively.ConclusionsThis meta-analysis supports the finding that chronic comorbidities may contribute to severe outcome in patients with COVID-19. According to the findings of the present study, old age and 2 or more comorbidities are significantly impactful to COVID-19 outcomes in hospitalized patients in China.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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