• Medicine · Mar 2021

    Effectiveness and safety review of Chinese herbal sachets for external use in the treatment of COVID-19 pandemic: A protocol for systematic review and meta-analysis.

    • Jing Ju, Chunchun Yan, Haoran Wang, Yi Ding, Yongchen Zhang, and Hongling Jia.
    • Acupuncture and Tuina College, Shandong University of Traditional Chinese Medicine.
    • Medicine (Baltimore). 2021 Mar 26; 100 (12): e25156e25156.

    BackgroundCOVID-19 has strong transmission power, and people are generally susceptible to it. Patients with weak constitution and low immunity function are more likely to be infected. Aromatic therapy of traditional Chinese medicine has the effect of inhibiting virus and sterilization, especially the external treatment of traditional Chinese medicine has played an important role in the fight against the epidemic situation.MethodsNine databases will be searched under the guideline of research strategy, from their inception to March 31, 2021, for relevant randomized controlled trial (RCTs) published. These databases are Cochrane Library, PubMed, EMBASE, Web of Science, ScienceDirect, China National Knowledge Infrastructure, Wan-fang Data, Chinese Scientific Journal Database, and Chinese Biomedical Literature Database. The types on Language of literature are English and Chinese. Researchers will independently operate the literature research, screening, quality evaluation, data collection, and data analysis with same research strategy and selection criteria. Methodological quality will be evaluated under the guideline of the Cochrane Collaboration's tool. Grading of Recommendations, Assessment, Development and Evaluation (GRADE) will be used to determine confidence in the effect estimates. Meta-analysis or subgroup analysis will be performed according to the including data type. Meta-analysis will be performed with Stata 13.0 software.ResultsOutcome will be displayed by effective rates, quality of life score, adverse effect.ConclusionThis systematic review will provide evidence whether Chinese herbal sachets are effective and safe intervention of COVID-19 Pandemic.Registration Number In ProsperoCRD42021238580.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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