• Chunwei Zhang, Ke Yang, Ying Yang, and Gang Zhao.
• Department of cardiovascular, Clinical Medical College &Afiliated Hospital of Chengdu University, Chengdu University, Chengdu, Sichuan Province.
• Medicine (Baltimore). 2021 Mar 26; 100 (12): e25157e25157.

BackgroundAs immune checkpoint pathways, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) can be exploited by tumor cells to evade immuno-surveillance. Inflammation and immune processes play decisive roles in the occurrence and development of coronary heart disease (CHD). The low expression level of PD-1/ PD-L1 or anti-PD-1/PD-L1 therapy can accelerate the immune processes in CHD and aggravates disease based on numerous studies. However, the expression of PD-L1 and CHD still remains controversial to date. We conducted this meta-analysis to detect the value of PD-L1 expression on peripheral T-cells in CHD.MethodsWe will search PubMed, Embase, Web of Science, Google Scholar, Chinese National Knowledge Infrastructure, Chinese VIP Information, Wanfang Database, and Chinese Biomedical Literature Database for related published studies before February 2021. Two review authors will search and assess relevant studies independently. Case control studies and cohort studies will be included. The Revman 5.3 software was applied to carry out the meta-analysis for the included literature.ResultsThe findings of this systematic review will be disseminated in a peer-reviewed publication and/or presented at relevant conferences.ConclusionThis study will provide a new theoretical basis for the immunological prevention and treatment of CHD.Trial Registration NumberDOI 10.17605/OSF.IO/X3R52.Ethics And DisseminationFormal ethical approval is not required, as the data are not individualized.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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