• Huixian Xie, Yiping Tang, Fengmin Cheng, and Jucai Chu.
• Department of Nursing.
• Medicine (Baltimore). 2021 Mar 26; 100 (12): e25241e25241.

BackgroundThere are no clinical trials evaluating the efficacy of combined music and Tai Chi therapy for patients with major depression. Therefore, the primary objective of the present study was to evaluate the efficacy of Tai Chi and music therapy on psychological status and quality of life among patients with major depressive disorder in China.MethodsThis work is a part of a comprehensive research project to assess and provide intervention that potentially improves psychological status and quality of life among patients with major depressive disorder. This research project has been received ethical approval from the Medical Research and Ethics Committee in Taizhou Second People's Hospital (no. tzey2020023). After the introductory briefing, the acceptance to take the presession questionnaire implied the participant's consent to participate in the study. Eligible participants are divided into 3 groups according to completely randomized design: combined group (music therapy + Tai Chi), music therapy alone group, and Tai Chi alone group. The analyses will be performed using SPSS 22.0.0 (SPSS Inc, Chicago, IL).ResultsThis protocol will provide a reliable theoretical basis for the following research.ConclusionThe sample came from a single health center. Therefore, the results cannot be generalized for the entire population.Trial RegistrationThis study protocol was registered in Research Registry (researchregistry6597).Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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