• Marco Piastra, Concezio Di Rocco, Elena Caresta, Giulia Zorzi, Daniele De Luca, Massimo Caldarelli, Giuseppe La Torre, Giorgio Conti, Massimo Antonelli, Simon Eaton, and Domenico Pietrini.
• Pediatric Intensive Care Unit, Catholic University "A. Gemelli" Hospital, L.go Gemelli 8, Rome 00168, Italy. marco_piastra@yahoo.it
• J. Neurooncol. 2008 Nov 1; 90 (2): 191-200.

ObjectiveTo evaluate perioperative management, early outcomes and hemocoagulative disorders in infants up to 1 year old, undergoing neurosurgery for brain tumors removal.DesignRetrospective evaluation of prospectively collected data regarding all infants aged <1 year admitted to PICU from 1994 to 2004, following intracranial mass removal.Interventionsnone.SettingUniversity Hospital PICU in a tertiary neurosurgical referral centre.Patients And ParticipantsAll eligible infants were enrolled in the study. Population was constituted by 43 infants and subdivided in two groups, according to their intra-operative blood loss. Babies having blood loss exceeding the preoperative estimated volemia were classified in group A; the remaining babies were included in group B.ResultsIntraoperative transfusions, PICU length of stay, need for post-operative mechanical ventilation and cardiovascular support were all significantly higher in group A than in group B. No early postoperative mortality occurred. ROC analysis and multiple logistic regression showed the age as the only variable independently associated with blood loss exceeding preoperative volemia (cut-off 60.3 days; OR = 0.11, CI 0.02-0.55, sensitivity 82.4%; specificity 67%). Postoperatively, platelet count, prothrombin activity and fibrinogen resulted significantly depressed in group A, representing a dilutional coagulopathy. A marked dispersion of aPTT values was recorded in group B, where most infants exhibit aPTT shortening, suggesting a hypercoagulability status. Three episodes of clinical disseminated intravascular coagulation (DIC) were registered in group B.ConclusionsWe illustrated the relationships between intraoperative blood loss, transfusions and haemostatic impairment in babies following brain tumor removal. Youngest infants had the higher risk to experience hemocoagulative disorders. These infants showed significantly higher impact on the global PICU burden of care, as represented by the need of mechanical ventilation, cardiovascular support and PICU length of stay.

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