• Plos One · Jan 2014

    Clinical criteria replenish high-sensitive troponin and inflammatory markers in the stratification of patients with suspected acute coronary syndrome.

    • Barbara Elisabeth Stähli, Keiko Yonekawa, Lukas Andreas Altwegg, Christophe Wyss, Danielle Hof, Philipp Fischbacher, Andreas Brauchlin, Georg Schulthess, Pierre-Alexandre Krayenbühl, Arnold von Eckardstein, Martin Hersberger, Michel Neidhart, Steffen Gay, Igor Novopashenny, Regine Wolters, Michelle Frank, Manfred Bernd Wischnewsky, Thomas Felix Lüscher, and Willibald Maier.
    • Department of Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.
    • Plos One. 2014 Jan 1; 9 (6): e98626.

    ObjectivesIn patients with suspected acute coronary syndrome (ACS), rapid triage is essential. The aim of this study was to establish a tool for risk prediction of 30-day cardiac events (CE) on admission. 30-day cardiac events (CE) were defined as early coronary revascularization, subsequent myocardial infarction, or cardiovascular death within 30 days.Methods And ResultsThis single-centre, prospective cohort study included 377 consecutive patients presenting to the emergency department with suspected ACS and for whom troponin T measurements were requested on clinical grounds. Fifteen biomarkers were analyzed in the admission sample, and clinical parameters were assessed by the TIMI risk score for unstable angina/Non-ST myocardial infarction and the GRACE risk score. Sixty-nine (18%) patients presented with and 308 (82%) without ST-elevations, respectively. Coronary angiography was performed in 165 (44%) patients with subsequent percutaneous coronary intervention--accounting for the majority of CE--in 123 (33%) patients, respectively. Eleven out of 15 biomarkers were elevated in patients with CE compared to those without. High-sensitive troponin T (hs-cTnT) was the best univariate biomarker to predict CE in Non-ST-elevation patients (AUC 0.80), but did not yield incremental information above clinical TIMI risk score (AUC 0.80 vs 0.82, p = 0.69). Equivalence testing of AUCs of risk models and non-inferiority testing demonstrated that the clinical TIMI risk score alone was non-inferior to its combination with hs-cTnT in predicting CE.ConclusionsIn patients presenting without ST-elevations, identification of those prone to CE is best based on clinical assessment based on TIMI risk score criteria and hs-cTnT.

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