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- Yuko Yoshizumi, Hiromi Tomioka, Eiji Katsuyama, and Yoshinori Kawabata.
- Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Japan.
- Intern. Med. 2021 Sep 1; 60 (17): 2847-2851.
AbstractA 30-year-old non-smoking man was referred to our hospital for the further examination of abnormal shadows revealed by chest X-ray. He had mild shortness of breath. Chest computed tomography revealed a fine-grained dendritic shadow with diffuse calcification in both lungs and as well as emphysematous changes in the upper lung lobes. A surgical lung biopsy histology revealed diffuse pulmonary ossification complicated with lung laceration, vascular disruption, hemosiderosis, and emphysema, suggesting vascular Ehlers-Danlos syndrome (vEDS). However, the patient had no external physical signs or family history of vEDS and no COL3A1 gene mutations. We are closely monitoring this patient in the clinic.
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