• S Kamiyashiki and K Hashimoto.
• Department of Medical Engineering, Saitama Cardiovascular and Respiratory Center, Saitama, Japan.
• Kyobu Geka. 2003 May 1; 56 (5): 365-70.

UnlabelledSixteen patients undergoing aortocoronary bypass surgery under normothermic cardiopulmonary bypass were divided into 2 groups according to the either addition or none of pulsatility induced by intra-aortic balloon pumping (IABP). In those patients, hepatic blood flow was measured 3 times before, during and after cardiopulmonary bypass. Additionally, arterial and hepatic ketone body ratios [(AKBR) and (HKBR)], and hepatic venous saturation (ShvO2) were measured throughout and after the surgery.ResultsThe hepatic blood flows measured at 3 different times at the surgery were much more in the pulsatile group (p < 0.05). The values of AKBR, indicator of mitochondrial redox potential in hepatocytes, were maintained in nearly normal in the pulsatile group, but were suppressed in the non-pulsatile group. This trend was much more obvious in the values of HKBR. The significantly lower ShvO2 levels were observed in the non-pulsatile group during the cardiopulmonary bypass (p < 0.05).ConclusionsPulsatile normothermic cardiopulmonary bypass induced by IABP provides better liver perfusion and results in a better hepatic metabolism than non-pulsatile cardiopulmonary bypass.

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