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- Nathalie Etchart, Ana Hennino, Martin Friede, Karima Dahel, Monique Dupouy, Catherine Goujon-Henry, Jean-François Nicolas, and Dominique Kaiserlian.
- INSERM U404, Lyon F-69007, France; Université Lyon 1, Lyon F-69003, France; IFR128, Lyon F-69007, France.
- Vaccine. 2007 Sep 28; 25 (39-40): 6891-9.
AbstractTranscutaneous immunisation (TCI) using a skin patch is a non-invasive vaccination route relevant to mass vaccination against infectious diseases. This phase I/II clinical study, documents that TCI of human adult volunteers with the live-attenuated measles vaccine ROUVAX((R)) is safe and poorly reactogenic. It promotes induction of measles-specific salivary IgA and a tendency to increased frequency of MV-specific IFNgamma-producing T cells. However, in contrast to the subcutaneous route, TCI failed to evoke neutralising MV-specific serum antibodies. Thus, alternative delivery methods and/or devices providing optimal uptake by skin DC should be considered for live-attenuated virus vaccines, such as the measles vaccine.
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