• Arch Orthop Trauma Surg · Oct 2012

    Blood transfusion and cytokines' changes in total knee replacement.

    • Georgios I Drosos, Konstantinos S Blatsoukas, Athanasios Ververidis, Grigorios Tripsianis, Pelagia Chloropoulou, Christos Iatrou, Konstantinos Kazakos, and Dionisios-Alexandros Verettas.
    • Medical School, University General Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece. drosos@otenet.gr
    • Arch Orthop Trauma Surg. 2012 Oct 1;132(10):1505-13.

    IntroductionThe aim of this prospective comparative study was to evaluate the serum levels of different cytokines and the frequency of adverse reactions and wound infections in patients who underwent total knee replacement (TKR) and were not transfused or received either allogeneic blood transfusion or postoperative auto-transfusion (PAT) with unwashed shed blood.Materials And MethodsA total of 248 patients were categorized into three groups; in Group 0 (n 85) patients received no blood transfusion, in Group 1 (n 92) patients received PAT and in Group 2 (n 71) patients received allogeneic blood transfusion. Patient's demographic and clinical data including age, gender, body mass index, preoperative haemoglobin value, adverse reactions and complications were documented. The serum levels of IL-1b, IL-6, IL-8, IL-10 and TNF were measured preoperatively, and on the first, third and fifth postoperative day. A statistical analysis of the results was performed.ResultsA significant elevation of cytokine values were observed during the first five postoperative days in patients who received blood transfusion after TKR. Adverse reactions (chills and pyrexia) were also more common in patients who received blood transfusion, whereas superficial infections were more common in patients who received allogeneic blood transfusion.ConclusionThe immunological status-as expressed by the measured cytokine levels-is altered in patients receiving blood transfusion compared to patients receiving no blood transfusion during the first five postoperative days. PAT is preferable to allogeneic blood transfusion in terms of the rate of adverse reactions and superficial wound infections.

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