• J. Am. Coll. Surg. · Jun 2021

    Review

    Fibrinolysis Shutdown in COVID-19: Clinical Manifestations, Molecular Mechanisms, and Therapeutic Implications.

    • Jonathan P Meizoso, Hunter B Moore, and Ernest E Moore.
    • Ernest E Moore Shock Trauma Center, Denver Health Medical Center, University of Colorado, Denver, CO. Electronic address: jonathan.meizoso@cuanschutz.edu.
    • J. Am. Coll. Surg. 2021 Jun 1; 232 (6): 9951003995-1003.

    AbstractThe COVID-19 pandemic has introduced a global public health threat unparalleled in our history. The most severe cases are marked by ARDS attributed to microvascular thrombosis. Hypercoagulability, resulting in a profoundly prothrombotic state, is a distinct feature of COVID-19 and is accentuated by a high incidence of fibrinolysis shutdown. The aims of this review were to describe the manifestations of fibrinolysis shutdown in COVID-19 and its associated outcomes, review the molecular mechanisms of dysregulated fibrinolysis associated with COVID-19, and discuss potential implications and therapeutic targets for patients with severe COVID-19.Copyright © 2021 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

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