• Fangyong Jiang, Jin Yang, Linchao Zhang, Rongshan Li, Liuan Zhuo, Liping Sun, and Qin Zhao.
• Department of Cardiology, Liuzhou People's Hospital, Liuzhou, Guangxi, China.
• Clin Cardiol. 2014 Sep 1; 37 (9): 530-5.

BackgroundStatins reduce the incidence of cardiovascular events after percutaneous coronary intervention (PCI), but no clinical studies have investigated the role of statins in ischemia-reperfusion injury after PCI.HypothesisRosuvastatin could reduce ischemia-reperfusion injury in patients with acute coronary syndrome treated with PCI.ObjectivesWe investigated the effects of rosuvastatin on ischemia-reperfusion injury in patients with acute coronary syndrome after PCI and evaluated short-term prognosis.MethodsPatients scheduled for emergent PCI were given either rosuvastatin for ≥6 months (10 mg/d, every night; n = 55) or no statins (control group; n = 65). Serum superoxide dismutase activity, malondialdehyde, brain natriuretic peptide (BNP), and high-sensitivity C-reactive protein (hs-CRP) were determined before and after PCI, as well as left ventricular ejection fraction and left ventricular end-diastolic volume. Major adverse cardiac events were observed at follow-ups for 6 months.ResultsSuperoxide dismutase activity in the rosuvastatin-treated group was higher than that of the control group; serum levels of malondialdehyde were lower. BNP and hs-CRP levels in the rosuvastatin-treated group were lower than that of the control group. Four weeks after PCI, the left ventricular ejection fraction in the treatment group was higher than that of the control group, and the left ventricular end-diastolic volume was lower. At the 6-month follow-up, there was no difference in major adverse cardiac events between the 2 groups.ConclusionsRosuvastatin before PCI reduced ischemia-reperfusion injury in patients with acute coronary syndrome, which suggests the importance of application of rosuvastatin before PCI for early intervention.© 2014 Wiley Periodicals, Inc.

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