• Pediatric emergency care · Apr 2021

    Adverse Drug Event-Related Admissions to a Pediatric Emergency Unit.

    • Indira Valadê Carvalho, Vanessa Marcilio de Sousa, Marília Berlofa Visacri, Júlia Coelho França Quintanilha, Cinthia Madeira de Souza, Rosiane Fátima Lopes Ambrósio, Marcelo Conrado Dos Reis, Rachel Alvarenga de Queiroz, Priscila Gava Mazzola, Taís Freire Galvao, and Patricia Moriel.
    • From the School of Medical Sciences.
    • Pediatr Emerg Care. 2021 Apr 1; 37 (4): e152e158e152-e158.

    ObjectivesThe objectives of this study were to analyze adverse drug events (ADEs) related to admissions to a pediatric emergency unit and to identify the associated risk factors.MethodsThis was a prospective study. Demographic data and details of medications were collected for each patient admitted. Case studies were performed by clinical pharmacists and the clinical team to discuss whether the admission was due to an ADE and to characterize the ADE. Multivariate logistic regression was used for statistical analysis.ResultsIn total, 1708 pediatric patients were included in this study. Adverse drug events were the cause of hospital admission in 12.3% of the studied population. The majority of patients presenting with an ADE were in the age group of 0 to 5 years (61.6%), had a mean ± SD age of 4.9 ± 3.9 years, were female (51.2%), were Caucasian (72.0%), and had infectious disorders (49.3%). High frequencies of medication errors (68.8%), use of drugs to treat respiratory disorders (27.7%), and ADEs of mild severity (75.3%) were reported. The risk of being admitted to the pediatric emergency unit for any ADE increased in cases of neurological (odds ratio [OR], 4.63; 95% confidence interval [CI], 2.38-8.99), dermatological (OR, 3.16; 95% CI, 1.93-5.18), and respiratory (OR, 3.02; 95% CI, 1.89-4.83) disorders.ConclusionsA high frequency of ADE-related admissions to the pediatric emergency unit was observed. The risk of being admitted to the pediatric emergency unit for any ADE increased in cases of neurological, dermatological, and respiratory disorders. Clinical pharmacists play an important role in the identification of ADEs and the education of child caregivers and health care providers concerning pediatric medication.Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.

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