• Scott M LaValva, Jason B Anari, John M Flynn, and Harms Study Group.
• Department of Orthopaedic Surgery, Children's Hospital of Philadelphia, The University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
• Spine Deform. 2021 Jul 1; 9 (4): 1063-1072.

Study DesignRetrospective case-control.ObjectiveTo identify a cohort of patients with persistent coronal imbalance (CIB) or revision surgery 5 years following fusion to an L3 lowest-instrumented-vertebra (LIV) and determine factors that make an L3 LIV high-risk. In surgical planning for AIS, L3 is chosen over L4 whenever possible to maximize motion segments below the LIV. Though fusion to an L3 LIV is common, the rate of failure and its risk factors have not been described.MethodsIn this analysis of prospectively-collected multi-center data of AIS patients who underwent posterior spinal fusion (PSF) to an L3 LIV, we identified patients with CIB at 5 years and/or those who required revision surgery attributable to LIV selection. Patients who were balanced at 5 years and did not require revision surgery served as controls. Pre-operative patient and radiographic variables were compared between cases and controls to identify risk factors for CIB/revision surgery.ResultsWe identified 646 patients with 2-year follow-up and 225 patients with 5-year follow-up, of which 11 were found to have CIB and/or revision surgery attributable to selecting L3 as the LIV. There were statistically significant differences between cases and controls with respect to several pre-operative factors, including BMI (24.5 in cases vs. 20.1 in controls; p = 0.01), Lenke curve type (81.8% Lenke 5/6 vs. 44.4%; p = 0.03), lumbar curve magnitude (56 vs. 45°; p < 0.01), TL/L apical vertebral translation (AVT) (6.2 vs. 4.1 cm; p < 0.01), L3 angulation (30° vs. 22°; p < 0.01), L3 translation (4.3 vs. 2.9 cm; p < 0.01), thoracic rib hump (7° vs. 12°; p = 0.02), lumbar rib hump (16° vs. 10°; p < 0.01), and thoracolumbar (T10-L2) kyphosis (10.5° vs. 2°; p = 0.006). Multivariate logistic regression showed that pre-operative BMI, TL/L AVT, L3 angulation, L3 translation, lumbar rib hump, and thoracolumbar kyphosis were independent predictors of CIB/revision surgery.ConclusionsAn L3 LIV is frequently successful at 5 years post-operatively. Consider an L4 LIV when: pre-operative BMI ≥ 28, L3 angulation ≥ 25°, L3 translation ≥ 4 cm, TL/L AVT ≥ 6 cm, or the lumbar curve is large (≥ 55°) and rotated (≥ 10°).Level Of EvidenceLevel III.© 2021. Scoliosis Research Society.

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