• Qi Wang, Jun Liu, Rong Fan, Yu Chen, Hailong Yu, Yan Bi, Zhengzhe Hua, Meihui Piao, Mingming Guo, Weijian Ren, and Liangbi Xiang.
• Department of Orthopedics, The General Hospital of Shenyang Military Area Command, No. 83, Wenhua Road, Shenyang, 110840, China, wangqi_orth@126.com.
• Eur Spine J. 2013 Sep 1;22(9):2035-8.

Study DesignThis study is randomized controlled trial.PurposeTo evaluate the effect of tranexamic acid (TXA) on reducing postoperative blood loss in posterior approach lumbar surgery for degenerative lumbar instability with stenosis.MethodsSixty patients with degenerative lumbar instability with stenosis were randomized into TXA and control groups, receiving 15 mg/kg body weight of TXA or placebo (0.9 % Sodium chloride solution) intravenously, respectively, before the skin incision was made. The operation of pedicle screw system fixation was performed for all patients, and then selective laminectomy and posterior lumbar interbody fusion (PLIF) were carried out. Intraoperative and postoperative blood loss were compared between the two groups. And the complication of TXA was also investigated.ResultsThere were no statistically significant differences between the TXA and control groups in terms of age, sex, body mass index, and operation time. There was no significantly difference in intraoperative blood loss between the two groups. However, in the TXA group, postoperative blood loss was significantly lower than that in the control group (13.0 %). Especially, postoperative blood loss during the first 12 h was reduced by 29.9 % as compared to the control group. There were no thromboembolic events or other complications occurred in either group.ConclusionsPreoperative single-dose TXA can significantly reduce postoperative blood loss in posterior approach lumbar surgery, and there were no significant side effects.

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