• Xingyao Hu, Guangbin Shang, Jie Zhang, Zhong Chen, Liu Fu, Jun Li, and Xiaonan Lu.
• Research Center for Differention and Development of TCM Basic Theory.
• Medicine (Baltimore). 2021 Apr 2; 100 (13): e24530e24530.

BackgroundAt present, Liver Cirrhosis (LC) is common in most later liver and gallbladder diseases that its morbidity and mortality seriously affect human health. The limitation and effectiveness of western medicine on LC have become a huge clinical challenge. However, a large number of clinical studies have shown that Yi-guan decoction has become a complementary treatment for LC. Therefore, this systematic review will aim to explore the safety and feasibility of Yi-guan decoction in the treatment of LC.MethodsWe will conduct a comprehensive literature search in Medline, PubMed, Cochrane Database of Systematic Reviews, Embase, Chinese Biomedical Literatures Database, China National Knowledge Infrastructure, Wang Fang Database, Chinese Scientific Journal Database from inception to December 2020 without any language restriction, In addition, relevant literature will be searched manually. The main subject terms searched: "Yi-guan decoction" "cirrhosis" "LC". Data entry will be performed by 2 researchers separately. Primary outcomes will be concluded: Liver function indicators: Total bilirubin, Alanine transaminase, Aspartate aminotransferase, etc. Secondary outcome indicators: Total effective rate, Nutrition index, Survival analysis, Adverse events; All randomized controlled trials collected in this study will be evaluated and rated using the Cochrane risk-of-biasassessment tool. Meta-analysis will be performed using RevMan 5.4.0 software. The heterogeneity test will be conducted between the studies, P < .1 and I2 > 50% are the thresholds for the tests. Using solid effect model or random effect model will be based on its heterogeneity value.ResultsThis systematic review provides a theoretical basis for Yi-guan decoction to treat LC, we will report this result soon.ConclusionThis study will explore Yi-guan decoction can will be used as one of the non drug therapies to prevent or treat LC.Trial Registration NumberINPLASY2020120114.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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