• Medicine · Apr 2021

    The systemic treatment of uterine leiomyosarcomas: A systematic review. No news is good news?

    • Anastasios Kyriazoglou, Michalis Liontos, Ioannis Ntanasis-Stathopoulos, and Maria Gavriatopoulou.
    • Department of Clinical Therapeutics, Alexandra General Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
    • Medicine (Baltimore). 2021 Apr 2; 100 (13): e25309e25309.

    BackgroundUterine leiomyosarcomas are rare malignant mesenchymal tumors. The systemic treatment of these tumors includes chemotherapy and radiotherapy. However, there are still a lot of unanswered questions regarding the ideal therapeutic approach.MethodsWe have conducted a systematic review of the treatment strategies of uterine leiomyosarcomas for the last ten years.ResultsAdjuvant chemotherapy is still a matter of dilemma. Doxorubicin based chemotherapy or the combination of Gemcitabine-Docetaxel are the regimens of choice for the first line setting. Beyond the first line, there are several options;, including chemotherapy, targeted therapy, and recently efforts of introducing immunotherapy to the therapeutic armamentarium of clinicians treating uterine leiomyosarcomas.ConclusionsDespite the efforts of the clinicians dealing with uterine leiomyosarcomas, the optimal therapeutic algorithm is yet to be described.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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