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- John D Lee and Trent M Woodruff.
- School of Biomedical Sciences, University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia.
- Trends Neurosci. 2021 Feb 1; 44 (2): 81-82.
AbstractIn a recent study, Yu et al. demonstrated that TAR DNA-binding protein of 43 kDa (TDP-43) causes inflammation in amyotrophic lateral sclerosis (ALS) by triggering mitochondrial (mt)DNA release into the cytoplasm, which subsequently activates the cytoplasmic DNA-sensing cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway. These results suggest that inhibition of cGAS/STING could help mitigate inflammation-related neuropathology in ALS.Copyright © 2020 Elsevier Ltd. All rights reserved.
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