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Ultrasound Med Biol · Jul 2014
Thermal fixation of swine liver tissue after magnetic resonance-guided high-intensity focused ultrasound ablation.
- Frédéric Courivaud, Airazat M Kazaryan, Alice Lund, Vivian C Orszagh, Aud Svindland, Marangos Irina Pavlik IP The Intervention Centre, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, Medical Faculty, University of Oslo, Oslo, Norwa, Per Steinar Halvorsen, Peter Jebsen, Erik Fosse, Per Kristian Hol, and Bjørn Edwin.
- The Intervention Centre, Oslo University Hospital, Oslo, Norway. Electronic address: Frederic.courivaud@rr-research.no.
- Ultrasound Med Biol. 2014 Jul 1; 40 (7): 1564-77.
AbstractThe aim of this study was to investigate experimental conditions for efficient and controlled in vivo liver tissue ablation by magnetic resonance (MR)-guided high-intensity focused ultrasound (HIFU) in a swine model, with the ultimate goal of improving clinical treatment outcome. Histological changes were examined both acutely (four animals) and 1 wk after treatment (five animals). Effects of acoustic power and multiple sonication cycles were investigated. There was good correlation between target size and observed ablation size by thermal dose calculation, post-procedural MR imaging and histopathology, when temperature at the focal point was kept below 90°C. Structural histopathology investigations revealed tissue thermal fixation in ablated regions. In the presence of cavitation, mechanical tissue destruction occurred, resulting in an ablation larger than the target. Complete extra-corporeal MR-guided HIFU ablation in the liver is feasible using high acoustic power. Nearby large vessels were preserved, which makes MR-guided HIFU promising for the ablation of liver tumors adjacent to large veins.Copyright © 2014 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
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