• Qifeng Wang, Rui Guo, Shunkang Rong, Gang Yang, Que Zhu, Yonghong Jiang, Changming Deng, Dichuan Liu, Qi Zhou, Qi Wu, Shunhe Wang, Jun Qian, Qi Wang, Han Lei, Tong-Chuan He, Zhibiao Wang, and Jing Huang.
• The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
• J. Am. Coll. Cardiol. 2013 May 28; 61 (21): 2185-92.

ObjectivesThis study investigated the feasibility of noninvasive renal sympathetic denervation (RSD) by using the novel approach of extracorporeal high-intensity focused ultrasound (HIFU).BackgroundCatheter-based RSD has achieved promising clinical outcomes.MethodsUnder the guidance of Doppler flow imaging, therapeutic ablations (250 W × 2 s) were performed by using extracorporeal HIFU on the bilateral renal nerves (36.3 ± 2.8 HIFU emissions in each animal) in a mean 27.4-min procedure in 18 healthy canines of the ablation group. Similar procedures without acoustic energy treatment were conducted in 5 canines of the sham group. The animals were killed on day 6 or 28. Blood pressure (BP), plasma noradrenaline (NA) level, and renal function were determined on days 0, 6, and 28. Pathological examinations were performed on all retrieved samples.ResultsAll of the animals survived the treatment. After ablation, BP and NA significantly decreased compared with the baseline values (BP changed -15.9/-13.6 mmHg, NA changed -55.4% [p < 0.001] 28 days after ablation]) and compared with the sham group on days 6 and 28. Ablation lesions around the renal artery adventitia were observed on day 6. A histological examination revealed the disruption of nerve fibers, necrosis of Schwann cells and neurons, and apparent denervation on day 28. No procedure-related complications were observed.ConclusionsEffective RSD was successfully achieved by using the extracorporeal HIFU method in canines. Thus, noninvasive HIFU may be further explored as an important and novel strategy for RSD.Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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