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Int. J. Clin. Oncol. · Dec 2011
Case ReportsA case of acute aortic thrombosis after cisplatin-based chemotherapy.
- Suk Jae Hahn, Jin Young Oh, Jeung Sook Kim, and Kim Do Yeun DY.
- Department of Internal Medicine, Dongguk University Ilsan Hospital, 814 Sicksadong Ilsandong-gu, Goyang 410-773, South Korea.
- Int. J. Clin. Oncol. 2011 Dec 1; 16 (6): 732-6.
AbstractCisplatin-based therapy is associated with various toxicities, including renal failure and neuropathy. However, acute arterial thrombosis is also a possible toxic effect of cisplatin, one that has been documented in a few cases worldwide. Here we present a rare case of ascending aortic thrombosis occurring 9 days after cisplatin-based chemotherapy in a 74-year-old male who was diagnosed with malignant pleural effusion suggestive of non-small cell lung cancer. The patient did not have any predisposing factor for the occurrence of an aortic thrombus before cisplatin-based chemotherapy. Thus, we suggest that the hypercoagulable state occurred secondary to cisplatin-based chemotherapy and was additive to the malignancy itself, causing aortic thrombosis. The patient was treated successfully with low-molecular-weight heparin and warfarin.
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