-
Multicenter Study
Watchful waiting for small non-functional pancreatic neuroendocrine tumours: nationwide prospective cohort study (PANDORA).
- C M Heidsma, A F Engelsman, S van Dieren, M W J Stommel, I de Hingh, M Vriens, L Hol, S Festen, L Mekenkamp, F J H Hoogwater, F Daams, H-J Klümpen, M G Besselink, C H van Eijck, and E J Nieveen van Dijkum.
- Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
- Br J Surg. 2021 Aug 19; 108 (8): 888891888-891.
AbstractThis prospective nationwide cohort study examined the feasibility of a watchful-waiting protocol for non-functional pancreatic neuroendocrine tumours (NF-pNET) of 2 cm or smaller. In total, 8 of 76 patients (11 per cent) with a NF-pNET no larger than 2 cm showed significant tumour progression (more than 0.5 cm/year) during 17 months of follow-up, of whom two opted for resection. No patient developed metastases. Quality of life was poorer than in the reference population. Watchful waiting seems a safe alternative to upfront surgery in patients with a NF-pNET no larger than 2 cm, although longer follow-up is necessary.
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