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- Masami Nishio, Kojiro Korematsu, Susumu Yoshioka, Yasuyuki Nagai, Tomoyuki Maruo, Yukitaka Ushio, Ryuji Kaji, and Satoshi Goto.
- Department of Neurosurgery, Otemae Hospital, Osaka, Japan.
- J Clin Neurosci. 2009 Nov 1; 16 (11): 1489-91.
AbstractDeep brain stimulation (DBS) of the ventral intermediate nucleus of the thalamus (VIM) is a powerful surgical option in the treatment of tremor-predominant Parkinson's disease. However, its therapeutic efficacy depends on the tremor distribution. DBS is highly efficient in relief of distal appendicular tremor but not other types of tremor. Also, it is generally thought that DBS of the VIM has no significant beneficial effects on other motor symptoms of Parkinson's disease. We report two hemiparkinsonian patients, in whom unilateral VIM DBS combined with posteroventral pallidotomy produced long-lasting suppression of not only hand tremor, but also leg or jaw tremor and other motor symptoms.
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