• Tie-Jun Shui, Chao Li, Hong-Bing Liu, Xiaohua Chen, and Bi-Ke Zhang.
• Yunnan Center for Disease Control and Prevention, Kunming, 650011, Yunnan, China.
• Bmc Infect Dis. 2020 Oct 13; 20 (1): 749.

BackgroundTwo months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients.MethodsThe clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China.ResultsIn total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively.ConclusionsSome patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation.Trial RegistrationCurrent Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered.

51 keywords...

hide…