• Raquel Sebio García, Maria Isabel Yáñez-Brage, Esther Giménez Moolhuyzen, Marta Salorio Riobo, Ana Lista Paz, and Jose María Borro Mate.
• 1 Physiotherapy Department, University of A Coruña, A Coruña, Spain.
• Clin Rehabil. 2017 Aug 1; 31 (8): 1057-1067.

ObjectivesTo investigate the effects of a preoperative pulmonary rehabilitation programme in patients with lung cancer undergoing video-assisted thoracic surgery.DesignRandomized, single-blind controlled trial.SettingTeaching hospital.SubjectsPatients with suspected or confirmed lung cancer undergoing video-assisted thoracic surgery.InterventionParticipants were randomized to either a prehabilitation group or a control group. Participants in the prehabilitation group underwent a combination of moderate endurance and resistance training plus breathing exercises three to five times per week.Main MeasuresThe primary outcome of the study was exercise capacity. Secondary outcomes were muscle strength (Senior Fitness Test), health-related quality of life (Short-Form 36) and the postoperative outcomes. Patients were evaluated at baseline (before randomization), presurgery (only the prehabilitation group), after surgery and three months post-operatively.ResultsA total of 40 patients were randomized and 22 finished the study (10 in the prehabilitation group and 12 in the control group). Three patients were lost to follow-up at three months. After the training, there was a statistically significant improvement in exercise tolerance (+397 seconds, p = 0.0001), the physical summary component of the SF-36 (+4.4 points, p = 0.008) and muscle strength ( p < 0.01). There were no significant differences between groups after surgery. However, three months postoperatively, significant differences were found in the mean change of exercise capacity ( p = 0.005), physical summary component ( p = 0.001) and upper and lower body strength ( p = 0.045 and p = 0.002).ConclusionsA pulmonary rehabilitation programme before video-assisted thoracic surgery seems to improve patients' preoperative condition and may prevent functional decline after surgery. Clinical Registration Number: NCT01963923 (Registration date 10/10/2013).

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