-
Anesthesia and analgesia · Dec 1987
Comparative StudyComparison of the toxicity of I-653 and isoflurane in rats: a test of the effect of repeated anesthesia and use of dry soda lime.
- E I Eger, B H Johnson, and L D Ferrell.
- Department of Anesthesia, University of California, San Francisco 94143-0542.
- Anesth. Analg. 1987 Dec 1; 66 (12): 1230-3.
AbstractThe low solubility and high stability of the new volatile anesthetic, I-653, suggest that this agent should have little or no toxic effect. This hypothesis was tested using repeated exposures to I-653, to isoflurane, or to no anesthetic. For 2 consecutive weeks, groups of 16 rats each were subjected to a total of six 2-hr exposures to 100% oxygen and 1.6 MAC I-653, isoflurane, or no anesthetic. Twenty-four hours after the last exposure, the rats were killed by administration of 100% carbon dioxide and then autopsied. Specimens were taken from brain, pituitary, lung, heart, duodenum, pancreas, kidney, and liver. No tissue damage attributable to either anesthetic was found nor was weight gain affected.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*
,_underline_
or**bold**
. - Superscript can be denoted by
<sup>text</sup>
and subscript<sub>text</sub>
. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3.
, hyphens-
or asterisks*
. - Links can be included with:
[my link to pubmed](http://pubmed.com)
- Images can be included with:
![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
- For footnotes use
[^1](This is a footnote.)
inline. - Or use an inline reference
[^1]
to refer to a longer footnote elseweher in the document[^1]: This is a long footnote.
.