• J. Am. Coll. Cardiol. · Nov 2011

    Multicenter Study

    Long-term outcomes after transcatheter aortic valve implantation in high-risk patients with severe aortic stenosis: the U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry.

    • Neil E Moat, Peter Ludman, Mark A de Belder, Ben Bridgewater, Andrew D Cunningham, Christopher P Young, Martyn Thomas, Jan Kovac, Tom Spyt, Philip A MacCarthy, Olaf Wendler, David Hildick-Smith, Simon W Davies, Uday Trivedi, Daniel J Blackman, Richard D Levy, Stephen J D Brecker, Andreas Baumbach, Tim Daniel, Huon Gray, and Michael J Mullen.
    • Royal Brompton and Harefield National Health Service (NHS) Foundation Trust, London, United Kingdom. n.moat@rbht.nhs.uk
    • J. Am. Coll. Cardiol. 2011 Nov 8; 58 (20): 2130-8.

    ObjectivesThe objective was to define the characteristics of a real-world patient population treated with transcatheter aortic valve implantation (TAVI), regardless of technology or access route, and to evaluate their clinical outcome over the mid to long term.BackgroundAlthough a substantial body of data exists in relation to early clinical outcomes after TAVI, there are few data on outcomes beyond 1 year in any notable number of patients.MethodsThe U.K. TAVI (United Kingdom Transcatheter Aortic Valve Implantation) Registry was established to report outcomes of all TAVI procedures performed within the United Kingdom. Data were collected prospectively on 870 patients undergoing 877 TAVI procedures up until December 31, 2009. Mortality tracking was achieved in 100% of patients with mortality status reported as of December 2010.ResultsSurvival at 30 days was 92.9%, and it was 78.6% and 73.7% at 1 year and 2 years, respectively. There was a marked attrition in survival between 30 days and 1 year. In a univariate model, survival was significantly adversely affected by renal dysfunction, the presence of coronary artery disease, and a nontransfemoral approach; whereas left ventricular function (ejection fraction <30%), the presence of moderate/severe aortic regurgitation, and chronic obstructive pulmonary disease remained the only independent predictors of mortality in the multivariate model.ConclusionsMidterm to long-term survival after TAVI was encouraging in this high-risk patient population, although a substantial proportion of patients died within the first year.Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

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