• Neuroreport · Jan 1996

    Decreased density of I2-imidazoline receptors in the postmortem brain of heroin addicts.

    • M Sastre, P Ventayol, and J A García-Sevilla.
    • Department de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Balears, Palma de Mallorca (Balears), Spain.
    • Neuroreport. 1996 Jan 31; 7 (2): 509-12.

    AbstractThe aim of this study was to quantitate imidazoline receptors in postmortem brains of heroin addicts who died of an opiate overdose. The density of I2-imidazoline receptors ([3H]idazoxan binding in the presence of adrenaline) and the immunoreactivity of the related 29/30 kDa imidazoline receptor protein were decreased (39% and 28%, respectively) in the frontal cortex. The density of brain I2-imidazoline receptors was also decreased in heroin-dependent rats (27%). This novel finding indicates that opiate addiction induces down-regulation of I2-imidazoline receptors in astrocytes, and presumably down-regulation of the functions associated with these receptors.

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