• Int. J. Clin. Pract. · Jul 2021

    Correlation of osteoprotegerin, sRANKL, inflammatory factors and epicardial adipose tissue volume with coronary heart disease.

    • Qiong He, Dan Ming, Dan Chen, Chuanlin Zhang, Hui Xie, and Shuang Wei.
    • Department of Cardiology, Renmin Hospital, Hubei University of Medicine, Shiyan, China.
    • Int. J. Clin. Pract. 2021 Jul 1; 75 (7): e14207.

    BackgroundTo observe the correlation of osteoprotegerin, soluble receptor activator of nuclear factor-κB ligand (sRANKL), inflammatory factors and epicardial adipose tissue volume (EATV) with the severity of coronary heart disease (CHD).MethodsWe studied 390 patients who were admitted to the Department of Cardiology of our hospital because of chest pain and underwent coronary angiography (CAG) from August 2018 to December 2019. According to CAG, 209 patients had non-CHD and 181 patients had CHD. Demographic data, biochemical indicators including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), lipoprotein a (Lp(a)), apolipoprotein B (apoB), apolipoprotein AI (apoAI), creatine kinase isoenzyme (CK-MB), osteoprotegerin, sRANKL, inflammatory factors (hs-CRP, FIB and IL-6), and EATV were collected.ResultsThe number of males, age, diabetes and hypertension in the CHD group was higher than those in the non-CHD group (P < .05). LDL-C, TC and apoB in the two groups were not significantly different (P > .05); HDL-C and apoAI in the CHD group were lower than those in the non-CHD group, and Lp(a) and CK-MB were higher than those in the control group (P < .05). Osteoprotegerin, IL-6, hs-CRP, EATV and FIB in the CHD group were higher than those in the non-CHD group, while sRANKL was lower than that in the control group (P < .05). Pearson correlation analysis showed that osteoprotegerin, sRANKL, inflammatory factors (hs-CRP, FIB and IL-6) and EATV were correlated with the severity of CHD (P < .05). Multivariate logistic regression analysis showed that CK-MB, osteoprotegerin, sRANKL, inflammatory factors (hs-CRP, FIB and IL-6) and EATV were risk factors for CHD, while HDL-C, Lp(a), apoAI were protective factors.ConclusionOsteoprotegerin, sRANKL, inflammatory factors and EATV were positively correlated with the severity of CHD, which had certain value for the diagnosis of CHD.© 2021 John Wiley & Sons Ltd.

      Pubmed     Full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…