• Bilal İlanbey, Ömer Faruk Elmas, Eser Yıldırım Sözmen, Ümran Günay, Abdullah Demirbaş, Mustafa Atasoy, Ümit Türsen, and Torello Lotti.
• Department of Medical Biochemistry, Faculty of Medicine, Ahi Evran University, Kırşehir, Turkey.
• Turk J Med Sci. 2021 Oct 21; 51 (4): 231823232318-2323.

Background/AimChitotriosidase (ChT) is an enzyme secreted by activated macrophages and neutrophils in response to proinflammatory signals. There is growing evidence indicating that ChT activity reflects the systemic inflammatory status. This study aimed to investigate whether serum ChT activity increased in patients with psoriasis and related comorbidities.Materials And MethodsThis cross-sectional study included 53 (28 with associated comorbidities and 25 without comorbidities) patients with psoriasis and 52 healthy volunteers. All participants underwent laboratory investigations for serum ChT levels, complete blood count, erythrocyte sedimentation rate, C-reactive protein, and serum lipid levels.ResultsThe patients with psoriasis showed significantly higher levels of ChT activity as compared to the healthy controls (23.5 ± 11.4 vs. 17.5 ± 10.4 μmol/mL/hour; p = 0.015). Additionally, the ChT activity was significantly higher in patients with comorbidities than in those without (p = 0.042).ConclusionOur data support the pathogenetic role of inflammatory processes induced by macrophage activation in patients with psoriasis and related comorbidities. We believe that high ChT activity in patients with psoriasis may serve as an early prediction of the possible related comorbidities.This work is licensed under a Creative Commons Attribution 4.0 International License.

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