• Lluís Campins, Mateu Serra-Prat, Inés Gózalo, David López, Elisabet Palomera, Clara Agustí, Mateu Cabré, and REMEI Group.
• Pharmacy Department. Hospital of Mataró, Consorci Sanitari del Maresme, Mataró, Barcelona, Spain.
• Fam Pract. 2017 Feb 1; 34 (1): 36-42.

BackgroundPolypharmacy is frequent in the elderly population and is associated with potentially drug inappropriateness and drug-related problems.ObjectivesTo assess the effectiveness and safety of a medication evaluation programme for community-dwelling polymedicated elderly people.DesignRandomized, open-label, multicentre, parallel-arm clinical trial with 1-year follow-up.SettingPrimary care centres.ParticipantsPolymedicated (≥8 drugs) elderly people (≥70 years).Study InterventionPharmacist review of all medication according to the Good Palliative-Geriatric Practice algorithm and the Screening Tool of Older Person's Prescriptions-Screening Tool to Alert Doctors to the Right Treatment criteria and recommendations to the patient's physician.Control InterventionRoutine clinical practice.MeasurementsRecommendations and changes implemented, number of prescribed drugs, restarted drugs, primary care and emergency department consultations, hospitalizations and death.ResultsAbout 503 (252 intervention and 251 control) patients were recruited and 2709 drugs were evaluated. About 26.5% of prescriptions were rated as potentially inappropriate and 21.5% were changed (9.1% discontinuation, 6.9% dose adjustment, 3.2% substitution and 2.2% new prescription). About 2.62 recommendations per patient were made and at least one recommendation was made for 95.6% of patients. The mean number of prescriptions per patient was significantly lower in the intervention group at 3- and 6-month follow-up. Discontinuations, dose adjustments and substitutions were significantly higher than in the control group at 3, 6 and 12 months. No differences were observed in the number of emergency visits, hospitalizations and deaths.ConclusionThe study intervention was safe, reduced potentially inappropriate medication, but did not reduce emergency visits and hospitalizations in polymedicated elderly people.© The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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