• Bella L Colombini, Karin C S Modena, Adriana M Calvo, Vivien T Sakai, Fernando P M Giglio, Thiago J Dionísio, Alceu S Trindade, José R P Lauris, and Carlos F Santos.
• Bauru School of Dentistry, São Paulo, Brazil.
• Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Aug 1; 102 (2): 169-74.

ObjectiveComparison of the clinical efficacy of 4% articaine in relation to 2% mepivacaine, both with 1:100,000 epinephrine, in the prevention of postoperative pain after lower third molar removal.Study DesignTwenty patients underwent removal of bilateral lower third molars under local anesthesia (articaine or mepivacaine) in 2 separate appointments, in a double-blind, randomized, and crossed manner. Objective and subjective parameters were recorded for paired comparison of postoperative courses.ResultsDuration of analgesia provided by articaine and mepivacaine was 198.00 +/- 25.86, and 125.40 +/- 13.96 min, respectively (P = .02), whereas the duration of anesthesia was 273.80 +/- 15.94 and 216.85 +/- 20.15 min, respectively (P = .06). Both solutions exerted no important effects upon arterial pressure, heart rate, or oxygen saturation (P > .05).ConclusionsArticaine provides a longer period of analgesic effect and a tendency for a longer period of anesthesia as compared to mepivacaine. The presence of a vasoconstrictor agent in local anesthetic solutions does not seem to influence hemodynamic parameters during lower third molar removal in healthy subjects.

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